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Beyond the Motor Cortex: Theta Burst Stimulation of the Anterior Midcingulate Cortex

Beyond the Motor Cortex: Theta Burst Stimulation of the Anterior Midcingulate Cortex

Authors: 
Travis E. Baker, Mei-Heng Lin, Malte Gueth, Kathryn Biernacki, Seema Parikh
Year: 
2020
Journal: 
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Abstract: 

Background

While the facilitatory and inhibitory effects of intermittent and continuous theta-burst stimulation (iTBS, cTBS) protocols have been well-documented on motor physiology, the action of TBS protocols on prefrontal functioning remain unclear. Here we asked whether iTBS or cTBS can differentially modulate reward-related signaling in the anterior midcingulate cortex (aMCC).

Methods

Across two experiments, we used a robot-assisted TMS system, combined with EEG recordings, to investigate the after-effects of prefrontal iTBS and cTBS on the reward positivity, an electrophysiological signal believed to index sensitivity of the aMCC to rewards. Twenty adults (aged 18–28) participated in Experiment 1 in which we used a scalp landmark for TBS targeting, and fourteen adults (aged 18–28) participated in Experiment 2, in which we aimed to increase TBS effectiveness by utilizing cortical thickness maps to select individualized DLPFC targets. 

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