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Global and local information processing in children with Pervasive Developmental Disorder (PDD): the role of spatial frequency processing

M.A. Boeschoten, C. Kemner, J.L. Kenemans, H. van Engeland
Under revision.
Abstract:
Converging evidence suggests that atypical global-local processing (i.e., a local bias) is an important feature of PDD. The neurocognitive basis of this phenomenon is unclear. This study tested whether a local bias in the Navon task in children with PDD was related to an abnormal processing of spatial frequency content. To this end, performance and event-related potentials (ERPs) in response to low-pass and high-pass filtered hierarchical stimuli were measured in children with PDD and matched controls.
In line with earlier findings, spatial frequency processing was abnormal in the children with PDD: they showed less robust spatial frequency-related differences in ERP amplitude at occipital electrodes in comparison to controls. Moreover, spatial frequency was associated with global-local processing. However, the atypical spatial frequency processing appeared not to be associated with abnormal global-local processing in the children with PDD. Instead, both groups of children showed the same effects of spatial frequency content on global-local processing as reflected by reaction time, ERP latency, and ERP amplitude.
In conclusion, although atypical spatial frequency processing might be an important characteristic of PDD, the findings of this study do not support it being an explanation for the abnormal global-local processing often seen in subjects with PDD. However, in this study stimulus properties may have obscured the findings on global-local processing. Therefore, more research using different types of filtered global-local stimuli is strongly recommended.

Publication by ANT staff

When a photograph can be heard: Vision activates the auditory cortex within 110ms

Proverbio, Alice Mado, D'Aniello, Guido Edoardo, Adorni, Roberta, Zani, Alberto
Scientific Reports, 1, 2011/08/04.
Abstract:
As the makers of silent movies knew well, it is not necessary to provide an actual auditory stimulus to activate the sensation of sounds typically associated with what we are viewing. Thus, you could almost hear the neigh of Rodolfo Valentino\'s horse, even though the film was mute. Evidence is provided that the mere sight of a photograph associated with a sound can activate the associative auditory cortex. High-density ERPs were recorded in 15 participants while they viewed hundreds of perceptually matched images that were associated (or not) with a given sound. Sound stimuli were discriminated from non-sound stimuli as early as 110 ms. SwLORETA reconstructions showed common activation of ventral stream areas for both types of stimuli and of the associative temporal cortex, at the earliest stage, only for sound stimuli. The primary auditory cortex (BA41) was also activated by sound images after ~ 200 ms.

A comparative study of cortical responses evoked by transcutaneous electrical vs CO2 laser stimulation

Marina de Tommaso, Roberto Santostasi, Vito Devitofrancesco, Giovanni Franco, Eleonora Vecchio, Marianna Delussi, Paolo Livrea and Zaza Katzarava
Clinical Neurophysiology, online 8 June, 2011.

Frontal phasic and oscillatory generators of the N30 somatosensory evoked potential

Cebolla AM, Palmero-Soler E, Dan B, Cheron G.
Neuroimage. 2010 Sep 7. (ahead of print), 2010.
Abstract:
The N30 component of somatosensory evoked potentials has been recognized as a crucial index of brain sensorimotor processing and has been increasingly used clinically. Previously, we have shown that the N30 is accompanied by both an increase of the power spectrum of the ongoing beta-gamma EEG (event related synchronization, ERS) and by a reorganization (phase-locking) of the spontaneous phase of this rhythm (inter-trials coherency, ITC). In order to localize its sources taking into account both the phasic and oscillatory aspects of the phenomenon, we here apply swLORETA methods on averaged signals of the event-related potential (ERP) from a 128 scalp-electrodes array in time domain and also on raw EEG signals in frequency domain at the N30 peak latency. We demonstrate that the two different mechanisms that generate the N30 component power increase (ERS) and phase locking (ITC) across EEG trials are spatially localized in overlapping areas in the precentral cortex, namely the motor cortex (BA4) and the premotor cortex (BA6). From this common region, the generator of the N30 event-related potential expands toward the posterior part of BA4, the anterior part of BA6 and the prefrontal cortex (BA9). These latter areas also present significant ITC sources in the beta-gamma frequency range, but without significant power increase of this rhythm. This demonstrates that N30 results from network activity that depends on distinct oscillating and phasic generators localized in the frontal cortex.

Publication by ANT staff

Early visually evoked electrophysiological responses over the human brain (P1, N170) show stable patterns of face-sensitivity from 4 years to adulthood

Dana Kuefner, Adelaide de Heering, Corentin Jacques, Ernesto Palmero-Soler and Bruno Rossion
2010.
Abstract:
Whether the development of face recognition abilities truly reflects changes in how faces, specifically, are perceived, or rather can be attributed to more general perceptual or cognitive development, is debated. Event-related potential (ERP) recordings on the scalp offer promise for this issue because they allow brain responses to complex visual stimuli to be relatively well isolated from other sensory, cognitive and motor processes. ERP studies in 5- to 16-year-old children report large age-related changes in amplitude, latency (decreases) and topographical distribution of the early visual components, the P1 and the occipito-temporal N170. To test the face specificity of these effects, we recorded high-density ERPs to pictures of faces, cars, and their phase-scrambled versions from 72 children between the ages of 4 and 17 and a group of , adults. We found that none of the previously reported age-dependent changes in amplitude, latency or topography of the P1 or N170 were specific to faces. Most importantly, when we controlled for age-related variations of the P1, the N170 appeared remarkably similar in amplitude and topography across development, with much smaller age-related decreases in latencies than previously reported. At all ages the N170 showed equivalent face-sensitivity: it had the same topography and right hemisphere dominance, it was absent for meaningless (scrambled) stimuli, and larger and earlier for faces than cars. The data also illustrate the large amount of inter- individual and inter-trial variance in young children`s data, which causes the N170 to merge with a later component, the N250, in grand-averaged data. Based on our observations, we suggest that the previously reported `bi-fid` N170 of young children is in fact the N250. Overall, our data indicate that the electrophysiological markers of face-sensitive perceptual processes are present from 4 years of age and do not appear to change throughout development

Robotized image-guided transcranial magnetic stimulation, a novel technique for functional brain-mapping

S. Kantelhardt, T. Fadini, M. Finke, K. Kallenberg, V. Bockermann, L. Matthaeus, J. Siemerkus, W. Paulus, A. Schweikard, V. Rohde
Clinical Neurophysiology, January 2009, (volume 120, issue 1, e84), 2009.

RP and N400 ERP components reflect semantic violations in visual processing of human actions

Proverbio AM, Riva F.
Neurosci Lett, 2009 May 7;PMID: 19427368, 2009.

Brain-Mapping using robotized TMS

Markus Finke, Tommaso Fadini, Sven Kantelhardt, Alf Giese, Lars Matthaus, Achim Schweikard
Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2008 (30, pages 3929-3932), 2008.

Comparison of functional brain mapping by computer controled roboterized transcranial-magnet-stimulation and functional MRI

Kantelhardt S.R., Fadini T., Kallenberg K., Finke M., Matthaus L, Schweikard A, Rohde V, Giese A.
Jahrestagung der Deutschen Gesellschaft fur Neurochirurgie (DGNC), Juni 2008 (59), 2008.

The neuronal sources of EEG : modeling of simultaneous scalp and intracerebral recordings in epilepsy.

Cosandier-Rimele D., Merlet I., Badier J.M., Chauvel P., Wendling F.
Neuroimage, 42(1): 135-146, 2008.
Abstract:
In many applications which make use of EEG to investigate brain functions, a central question is often to relate the recorded signals to the spatio-temporal organization of the underlying neuronal sources of activity. A modeling attempt to quantitatively investigate this imperfectly known relationship is reported. The proposed plausible model of EEG generation relies on an accurate representation of the neuronal sources of activity. It combines both an anatomically realistic description of the spatial features of the sources (convoluted dipole layer) and a physiologically relevant description of their temporal activities (coupled neuronal populations). The model was used in the particular context of epileptiform activity (interictal spikes) to interpret simultaneously generated scalp and intracerebral EEG. Its integrative properties allowed for the bridging between source-related parameters (spatial extent, location, synchronization) and the properties of resulting EEG signals (amplitude of spikes, amplitude gradient along intracerebral electrodes, topography over scalp electrodes). The sensitivity of both recording modalities to source-related parameters was also studied. The model confirmed that the cortical area involved in interictal spikes is rather large. Its relative location with respect to recording electrodes was found to strongly influence the properties of EEG signals as the source geometry is a critical parameter. The influence, on simulated signals, of the synchronization degree between neuronal populations within the epileptic source was also investigated. The model revealed that intracerebral EEG can reflect epileptic activities corresponding to weak synchronization between neuronal populations of the epileptic patch. These results, as well as the limitations of the model, are discussed.

Alpha and theta evoked brain oscillations underlie object selective attention processes

E. Alonso-Prieto, E. Palmero, J. Kanev, F. Zanow, A. Martinez
Brain Topography, 2007.

Publication by ANT staff

Abnormal spatial frequency processing in high functioning children with Pervasive Developmental Disorder (PDD)

M.A. Boeschoten, C. Kemner, J.L. Kenemans, H. van Engeland
Clinical Neurophysiology, Vol 118(9):2076-88, 2007.
Abstract:
OBJECTIVE: Basic abnormalities in visual information processing could be associated with the local visual bias often found in subjects with PDD. Therefore, the present study investigated the existence of deficits in spatial frequency processing at an early sensory level in children with PDD.
METHODS: Visual evoked potentials (VEPs) and VEP dipole sources elicited by high and low spatial frequency gratings were analysed in children with PDD and matched controls.
RESULTS: Children with PDD did not show the same robust differences between high and low spatial frequencies in VEP peaks (N80/P1) and VEP brain sources as control children, mainly because of atypical processing of high spatial frequencies.
CONCLUSIONS: Decreased specialized processing of high and low spatial frequencies might be a robust characteristic of PDD. Because the processing of local and global aspects in visual information is associated with the processing of high and low spatial frequencies, respectively (e.g., Goffaux et al., 2005; Boeschoten et al., 2005a), the present data suggest that the local visual bias in subjects with PDD might be associated with an abnormality spatial frequency processing.
SIGNIFICANCE: The existence of an abnormality in spatial frequency processing in PDD is validated

Publication by ANT staff

Face processing in Pervasive Developmental Disorder (PDD): the roles of expertise and spatial frequency

M.A. Boeschoten, C. Kemner, J.L. Kenemans, H. van Engeland
Journal of Neural Transmission, Jul 18, 2007.
Abstract:
Both a reduced face expertise and a basic abnormality in visual information, e.g. spatial frequency, processing have been proposed as possible causes of the abnormal face processing in PDD. This study investigated both the roles of expertise and spatial frequency for face processing in PDD. Event-related potentials (ERPs) and dipole sources were measured in response to (upright/inverted) high- and low-pass filtered faces, houses, and stimuli for which children with PDD were experts. ERP analyses for specific posterior electrodes showed no differences between children with PDD and matched controls, but source analyses did. These showed that controls activated specialized brain sources for the processing of faces, which was dependent on low spatial frequency content. However, PDD children did not. Importantly, present results argue against the idea that this is due to a reduced face expertise on the part of the PDD children, but instead support an abnormality in spatial frequency processing.

Publication by ANT staff

Novelty detection and encoding for declarative memory within the human hippocampus

T. Grunwald, M. Kurthen
Clin. EEG Neurosci., Oct;37(4):309-14, 2006.

Publication by ANT staff

Gender specific processing of eye contact within the human medial temporal lobe.

T. Grunwald, M. Vannucci, N. Pezer, M. Kurthen, J. Schramm, C.E. Elger
Clin. EEG Neurosci., 2006.

Publication by ANT staff

Influence of Anisotropic Conductivity on EEG Source Reconstruction: Investigations in a Rabbit Model

D. Guellmar, J. Haueisen, M. Eiselt, F. Giessler, L. Flemming, A. Anwander, T.R. Knoesche, C.H. Wolters, M. Duempelmann, D.S. Tuch, J.R. Reichenbach
IEEE Trans. Biomed. Eng., Vol. 53, No. 9, 1841-1850, 2006.
Abstract:
The aim of our work was to quantify the influence of white matter anisotropic conductivity information on electroencephalography (EEG) source reconstruction. We performed this quantification in a rabbit head using both simulations and source localization based on invasive measurements. In vivo anisotropic (tensorial) conductivity information was obtained from magnetic resonance diffusion tensor imaging and included into a high-resolution
finite-element model. When neglecting anisotropy in the simulations, we found a shift in source location of up to 1.3 mm with a mean value of 0.3 mm. The averaged orientational deviation was 10 degree and the mean magnitude error of the dipole was 29%%. Source localization of the first cortical components after median and tibial nerve stimulation resulted in anatomically verified dipole positions with no significant anisotropy effect. Our results indicate that the expected average source localization error due to anisotropic white matter conductivity is within the principal accuracy limits of current inverse procedures. However, larger localization errors might occur in certain cases. In contrast, dipole orientation and dipole strength are influenced significantly by the anisotropy. We conclude that the inclusion of tissue anisotropy information improves source estimation procedures.

Publication by ANT staff

Time-frequency filtering of MEG signals with matching pursuit.

M. Gratkowski, J. Haueisen, L. Arendt-Nielsen, AC. Chen, F. Zanow.
J Physiol Paris, 99(1):47-57, 2006.

Publication by ANT staff

Phase synchrony among ventral and dorsal visual streams during the integration of form and motion information

E. Alonso-Prieto. E. Palmero-Soler. M. Majtanik, K. Dolan, H. Mohlberg, K. Amunts, C. Rottschy, E. Aubert-VAzquez, K. Zilles, M.Niedeggen, P.A. Tass,
NeuroImage (CD-Rom), 2006.

Publication by ANT staff

Hippocampus proper distinguishes between identified and unidentified real-life visual objects: an intracranial ERP study.

M. Vannucci, T. Grunwald, N. Pezer, T. Dietl, C. Helmstaedter, C. Schaller, MP. Viggiano, C.E. Elger
Neuroscience Letters, 401(1-2):165-70, 2006.

Publication by ANT staff

A comparative study of MEG inverse methods: weighted Minimum Norm, MFT, and sLORETA

V. Hadamschek, E. Palmero-Soler, J. Dammers, T. Fieseler, P.A. Tass
In press, 2006.

Publication by ANT staff

Time-varying differences in evoked potentials elicited by high versus low spatial frequencies: a topographical and source analysis

M.A. Boeschoten, C. Kemner, J.L. Kenemans, H. van Engeland
Clinical Neurophysiology, Vol 116(8):1956-1966, 2005.
Abstract:
OBJECTIVE: To investigate time-varying differences in visual-evoked potentials (VEPs) and dipoles elicited by high versus low spatial frequencies. The main question was whether different spatial frequencies are processed in distinct cortical areas, especially after 100 ms. An additional question was whether and how a hemispheric balance in spatial frequency processing develops over time. METHODS: Stimuli were square-wave gratings, with spatial frequencies of 0.75, 1.5, and 6 c/d. VEPs and dipole models were analyzed at various latencies. RESULTS: For the time-window of 80-100 ms, spatial frequency-related differences in VEPs and dipoles in posterior regions as reported previously were replicated: lower spatial frequencies were associated with more positivity in the VEP and with more anterior and radial sources than high frequencies. However, after 100 ms differences in amplitude, but not in topography and dipoles, were found between the different spatial frequencies. Between 180-200 ms a right hemisphere dominance was found for all frequencies. CONCLUSIONS: After 100 ms, VEPs in response to different spatial frequencies seem to be generated in the same cortical areas. Also, no evidence for frequency-related hemispheric lateralization was found. SIGNIFICANCE: Insight is provided into the functional-anatomical basis of longer-latency frequency-related differences in processing.

Publication by ANT staff

The relationship between local and global processing and the processing of high and low spatial frequencies studied by event-related potentials and source modeling

M.A. Boeschoten, C. Kemner, J.L. Kenemans, H. van Engeland
Cognitive Brain Research, Vol. 24(2): 228-236, 2005.
Abstract:
The processing of global and local elements and of low- and high-spatial frequencies are thought to be interrelated. Evidence for this stems from findings showing that brain localizations for global/local elements and for low/high spatial frequencies seem to overlap. The present study aimed to provide direct evidence that topographical differences between the processing of global and local visual elements can directly be explained by their spatial frequency content, and to study at which point in time this relation is present. This was done by studying the event-related potentials (ERPs) and source models elicited by unfiltered, low- or high-pass filtered hierarchical stimuli. Results showed that performance for global and local targets was affected by removing low and high spatial frequencies, respectively. ERP data indicated that at 250 ms, there was an interaction between the processing of global/local targets and of spatial frequencies because at this time-point removal of low spatial frequencies decreased activity associated with the processing of global targets. When localizing this effect, we found evidence implying that spatial frequency content indeed affected the brain region in which local/global targets were processed. Results implicated that the processing of global information depended on its low spatial frequency content, which was processed more laterally. Instead, processing of local information seemed to depend on its high spatial frequency content, which was processed more medially. Thereby, present results extend former results showing that global and local processing is dependent on spatial frequency and mapped retinotopically in the visual cortex.

Publication by ANT staff

Temporal dynamics of visual motion processing in human cortical areas V1 and V5: a MEG study

E. Alonso-Prieto, U. Barnikol, E. Palmero-Soler, J. Dammers, T. Fieseler, S. Wuttich,
NeuroImage (CD-Rom), 26, 2005.

Publication by ANT staff

A comparison of the sLORETA method in the presence of noise with different prior functions

E. Palmero-Soler, V. Hadamschek, K. Dolan, J. Dammers and A.P. Tass
NeuroImage (CD-Rom), 26, 2005.

Publication by ANT staff

Global and local information processing in autism

M.A. Boeschoten
PhD Thesis, 2005.

Publication by ANT staff

ASA-Advanced Source Analysis of Continuous and Event-Related EEG/MEG Signals.

F. Zanow and T.R. Knoesche
Brain Topography, Volume 16, Number 4, pp. 287-290, 2004.

Publication by ANT staff

Influence of levodopa on cognition of idiopathic Parkinson's disease

E. Alonso-Prieto, E. Michel-Esteban, C. Trujillo-Matienzo, E. Palmero-Soler
Revista Neurologia, 19, 2004.

Publication by ANT staff

Cognitive diagnosis of cerebrovascular diseases by event related potentials: anatomical sources that generate P300

E. Alonso-Prieto, E. Palmero-Soler, E. Cuspineda-Bravo, E. Cordero-Eiriz, N. Trujillo-Barreto, C. Trujillo-Matienzo, O. Fernandez-Concepcion, A. Jimenez-Conde
Revista Neurologia, 38, 2004.

Publication by ANT staff

Even-related potentials and the diagnosis of short-term verbal memory disorders in cerebrovascular disease

E. Alonso-Prieto, E. Palmero-Soler, C. Trujillo-Matienzo, E. Cuspineda-Bravo, I. Suarez-Luis
Revista Neurologia, 39, 2004.

Publication by ANT staff

Event-related potentials and the diagnosis of short-term verbal memory disorders in cerebrovascular disease

E. Alonso-Prieto, E. Palmero-Soler, C. Trujillo-Matienzo, E. Cuspineda-Bravo, I. Suarez-Luis
Revista Neurologia, 2004.

Publication by ANT staff

Neuronal substrates of sensory gating within the human brain.

T. Grunwald, NN. Boutros, N. Pezer, J. von Oertzen, G. Fernandez, C. Schaller, C.E. Elger.
Biological Psychiatry, 15;53(6):511-9, 2003.

Publication by ANT staff

Development of an electrophysiological indicator of neural efficiency using ERPs.

D. Debatisse, S. Campanella, E. Pralong, M. Van de Velde, P. Gondoin, P.A. Despland, J.M. Lang, P. Maeder, E. Fornari, M. Gleis
Federation of European Physiological Societies.Bordeaux, FEPS 2003., Poster, 2003.

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A model-based approach to stabilizing crutch supported paraplegic standing by artificial hip joint stiffness

J.H. van der Spek, P.H. Veltink, H.J. Hermens, B.F. Koopman, H.B. Boom
IEEE Trans Neural Syst Rehabil Eng, 11(4):443-51., 2003.

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Static and dynamic evaluation of the influence of supplementary hip-joint stiffness on crutch-supported paraplegic stane.

J.H. van der Spek, P.H. Veltink, H.J. Hermens, B.F. Koopman, H.B. Boom
IEEE Trans Neural Syst Rehabil Eng, 11(4):452-62, 2003.

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Dissecting out conscious and unconscious memory (sub)processes within the human medial temporal lobe.

T. Grunwald, N. Pezer, TF. Munte, M. Kurthen, K. Lehnertz, D. Van Roost, G. Fernandez, M. Kutas, C.E. Elger.
Neuroimage., 20(1) suppl 1:S139-45, 2003.

Publication by ANT staff

MCMC for Bayesian Model Averaging in EEG/MEG imaging

N. Trujillo-Barreto, E. Palmero-Soler, L. Melie, E. Martinez
NeuroImage (CD-Rom), 19, 2003.

Publication by ANT staff

Hippocampal function and visual object processing in temporal lobe epilepsy.

M. Vannucci, T. Dietl, N. Pezer, MP. Viggiano, C. Helmstaedter, C. Schaller, C.E. Elger, T. Grunwald
Neuroreport., 6;14(11):1489-92, 2003.

Publication by ANT staff

Heterotopias, cortical dysplasias and glioneural tumors participate in cognitive processing in patients with temporal lobe epilepsy.

T. Kirschstein, G. Fernandez, T. Grunwald, N. Pezer, H. Urbach, I. Blumcke, D. Van Roost, K. Lehnertz, C.E. Elger.
Neuroscience Letters, 6;338(3):237-41., 2003.

Publication by ANT staff

Specific alterations in attention in the early stages of Parkinson's disease

E. Alsono-Prieto, E.M. Esteban, C. Trujillo-Matienzo, E. Lara-G. Fernandez, T. Rousso-Viota, A. Cordero-Eiriz
Revista Neurologia, 36, 2003.

Publication by ANT staff

Evaluation of a method for automatic detection of epileptic seizures from the electroencephalogram (EEG).

A. V. Sazonov, K. Schindler, M. Duempelmann, T. Loher, F. Donati, J. Mathis, P.J.M. Cluitmans
Epilepsia, 43, Supplement 7, p. 50, 2002.

Publication by ANT staff

Sensitivity of inverse source reconstruction results towards forward model inaccuracies: Application of a universal sensitivity analysis software framework on different tissue conductivity ratios.

M. Duempelmann, T.R. Knoesche, A. Anwander, C. Wolters
Proceedings BIOMAG 2002 13th International Conference on Biomagnetism, pp. 694-696, 2002.

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Use of event related potentials for the diagnosis and follow up of sub clinical disorders of sustained attention in ischemic cerebrovascular disease

E. Alonso-Prieto, M.A. Alvarez, A. Reyes-Verazain, O. Fernandez-Concepcion, E. Barros-Garcia, A. Pando-Cabrera
Revista Neurologia, 34, 2002.

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Usefulness of P300 as a tool for diagnosing alterations in sustained attention in ischemic cerebrovascular disease.

E. Alonso-Prieto, M.A. Alvarez-Gonzalez, O. Fernandez-Concepcion, A. Jimenez-Conde, C. Machado
Revista Neurologia, 34, 2002.

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Neuroanatomical structures mediating sensory gating in humans

N.N. Boutros, Th. Grunwald, N. Pezer, C.E. Elger
Biological Psychiatry, 49:8 Suppl., 209, 2001.

Publication by ANT staff

Inferior temporal stream for word processing with integrated mnemonic function.

G. Fernandez, P. Heitkemper, T. Grunwald, D. Van Roost, H. Urbach, N. Pezer, K. Lehnertz, C.E. Elger
Hum Brain Mapp , 14(4):251-60, 2001.

Publication by ANT staff

Object processing in the infant brain

C.S. Herrmann and A.D. Friederici
Science, 292:1632, 2001.

Cortical and depth data of P50 gating in humans: a report of two cases

N.N. Boutros, Th. Grunwald, N. Pezer, C.E. Elger
Biological Psychiatry, 47: Suppl, 454, 2000.

Publication by ANT staff

Estimation of the electric conductivity from scalp measurements: feasibility and application to source localization.

M.J. van Burik, M.J. Peters
Clinical Neurophysiology, 111(8):1514-21, 2000.

Publication by ANT staff

Clinical relevance of quantified interictal spike-activity in presurgical evaluation of epilepsy

A. Hufnagel, M. Duempelmann, J. Zentner, O. Schijns, C.E. Elger
Epilepsia, 41(4), 467-478, 2000.

Attention and memory

M.A. Alvarez, E. Alonso-Prieto
In Health and Psychology. Ed. Nunez de Villavicencio., 2000.

Publication by ANT staff

Syntactic gender and semantic expectancy: ERPs reveal early autonomy and late interaction

Th.C. Gunter, A.D. Friederici and H. Schriefers
Journal of Cognitive Neuroscience, 12: 556-568, 2000.

Magnetic brain activity evoked and induced by visually presented words and nonverbal stimuli

C. Eulitz, H. Eulitz, B. Maess, R. Cohen, C. Pantev. and T. Elbert
Psychophysiology, 37, 447-455, 2000.

Attention disorders in a sample of complex partial epileptic children.

E. Alonso-Prieto, M.A. Alvarez, A. Reyes-Verazain, E. Rojas, C. Romero, A. Pando
Revista Neurologia, 15, 2000.

Publication by ANT staff

EEG and implanted sources in the brain

M.J. van Burik, M.J. Peters
Arch Physiol Biochem, 107(5):367-75, 1999.

Publication by ANT staff

Context related artefact detection in prolonged EEG recordings.

M. van de Velde, I.R. Ghosh, P.J.M. Cluitmans.
Comp. Meth. Prog. Biomed., 60, 3: 183-196., 1999.

Publication by ANT staff

Visual and automatic investigation of epileptiform spikes in intracranial EEG-recordings

M. Duempelmann, C.E. Elger
Epilepsia, 40, 275-285, 1999.

Publication by ANT staff

Prediction of postoperative seizure control by hippocampal event-related potentials.

T. Grunwald, K. Lehnertz, N. Pezer, M. Kurthen, D. Van Roost, J. Schramm, C.E. Elger.
Epilepsia, 40(3):303-6, 1999.

Publication by ANT staff

Do intrahippocampally recorded spikes contribute to focus lateralization and prediction of the postoperative outcome in temporal lobe epilepsy?

M. Dumpelmann, M. Kurthen, Th. Grunwald, C.E. Elger
Epilepsia, 40, Suppl. 7, 212, 1999.

Publication by ANT staff

Timing of memory-related electrophysiological processes in temporal lobe epilepsy.

Th. Grunwald, N. Pezer, R. Hurlemann, M. Kurthen, K. Lehnertz, G. Fernandez, C.E. Elger
Epilepsia, 40: Suppl 7, 47, 1999.

Publication by ANT staff

Limbic P300s in temporal lobe epilepsy with and without Ammon's horn sclerosis.

T. Grunwald, H. Beck, K. Lehnertz, I. Blumcke, N. Pezer, M. Kutas, M. Kurthen, HM. Karakas, D. Van Roost, OD. Wiestler, C.E. Elger.
European Journal of Neuroscience, 11(6):1899-906, 1999.

Publication by ANT staff

Spatial mapping of ERD/ERS

M.J. van Burik, G. Edlinger, G. Pfurtscheller
Event-related desynchronization: handbook of electroencephalogy and clinical neurophysiology, G. Pfurtscheller and F.H. Lopes da Silva (Eds.), , vol. 6, 107-118, 1999.

Publication by ANT staff

Functional imaging of post movement beta event-related synchronization

M.J. van Burik, G. Pfurtscheller
J. Clin. Neurophysiology, 16 (3), 1999.

Publication by ANT staff

Serial processes of declarative memory formation in the human medial temporal lobe

G. Fernandez, Th. Grunwald, A. Effern, N. Pezer, K. Lehnertz, M. Duempelmann, C.E. Elger
Neuroimage, 96-921, 1999.

Publication by ANT staff

Physical properties of the skull

M.J. van Burik
PhD Thesis, 1999.

Publication by ANT staff

Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptors.

T. Grunwald, H. Beck, K. Lehnertz, I. Blumcke, N. Pezer, M. Kurthen, G. Fernandez, D. Van Roost, HJ. Heinze, M. Kutas, C.E. Elger.
Proc Natl Acad Sci U S A., 96(21):12085-9., 1999.

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Sub-clinical attention changes in transient ischemic attacks in the vertebrobasilar region

M.A. Alvarez, C. Machado, E. Barroso, A. Pando, O. Fernandez, R. Mestre, E. Alonso-Prieto
Revista Neurologia, 29, 1999.

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Real-time tracking of memory formation in the human rhinal cortex and hippocampus

G. Fernandez, A. Effern, T. Grunwald, N. Pezer, K. Lehnertz, M. Duempelmann, D. Van Roost, C.E. Elger
Science, 285, 1582-1585, 1999.

Publication by ANT staff

Here's looking at you: sex-specific processing of eye-contact within the human mesial temporal lobe.

N. Pezer, Th. Grunwald, PG. Falkai, C.E. Elger
Society for Neuroscience Abstracts (29th Annual Meeting of the Society for Neuroscience, Miami Beach, USA), 25:354, 1999.

Publication by ANT staff

High-resolution ERD using realistic head geometry.

A. Prull, G. Edlinger, M. van Burik, R. Stollberger, C. Neuper, G. Pfurtscheller
Biomedizinische Technik, 43 Suppl:240-1. , 1998.

Publication by ANT staff

Post-movement beta oscillations studied with linear estimation

M.J. van Burik, T.R. Knoesche, G. Edlinger, C. Neuper, G. Pfurtscheller, M.J. Peters
Electroencephalogr. Clin. Neurophysiol., 106(3):195-8, 1998.

Publication by ANT staff

Digital archival and exchange of events in a simple format for polygraphic recordings with application in event related potential studies.

M. van de Velde, M.M. van den Berg-Lenssen, G.J. van Boxtel, P.J. Cluitmans, B. Kemp, J. Gade, C.E. Thomsen, A. Varri
Electroencephalogr. Clin. Neurophysiol., 106(6):547-51, 1998.

Publication by ANT staff

Detection of muscle artefact in the normal human awake EEG

M. van de Velde, G. van Erp, P.J.M. Cluitmans.
Electroencephalogr. Clin. Neurophysiol., 107(2):149-58. , 1998.

Publication by ANT staff

Limbic ERPs predict verbal memory after left-sided hippocampectomy.

T. Grunwald, K. Lehnertz, C.Helmstaedter, M. Kutas, N. Pezer, M. Kurthen, D. Van Roost, C.E. Elger.
Neuroreport, 9(15):3375-8, 1998.

Publication by ANT staff

Automatic detection of epileptiform spikes in the electrocorticogram: A comparison of two algorithms

M. Duempelmann, C.E. Elger
Seizure, 7(2), 145-52, 1998.

Publication by ANT staff

Hipocampal cell counts and event-related potentials to words within the human mesial temporal lobe

Th. Grunwald, H. Beck, K. Lehnertz, I. Bluemcke, N. Pezer, OD. Wiestler, C.E. Elger
Society for Neuroscience Abstracts (28th Annual Meeting of the Society for Neuroscience, Los Angeles, USA), , 25:2115, 1998.

Publication by ANT staff

Post-movement EEG synchronization studied with different high resolution methods.

G. Edlinger, G. Pfurtscheller, M.J. van Burik, P. Wach
Brain Topography, 10(2):103-13. , 1997.

Publication by ANT staff

Cortical imaging based on an analytic high resolution EEG

G. Edlinger, P. Wach, T.R. Knoesche, M.J. van Burik, G. Pfurtscheller
Brain Topography, Vol 10(1) -P2.11, 1997.

Publication by ANT staff

Time/space regularization of the inward continuation problem in EEG using the boundary element method

M.J. van Burik, F. Zanow, G. Edlinger, M.J. Peters, G. Pfurtscheller
Brain Topography, Vol 10(1) -P2.44, 1997.

Publication by ANT staff

Reconstruction of the sources of the early left anterior negativity (ELAN)

T.R. Knoesche, B. Maess, Friederici A.D
Brain Topography , Vol 10(1) -P2.24, 1997.

Post-movement beta synchronization studied with linear estimation

M.J. van Burik, T.R. Knoesche, M.J. Peters, G. Pfurtscheller
Brain Topography , Vol 10(1) -P2.46, 1997.

Publication by ANT staff

The influence of skull parameters in a realistically shaped head model on the accuracy of EEG dipole localization

F. Zanow, M.J. Peters
Brain Topography , Vol 10(1) -P2.50, 1997.

Publication by ANT staff

Data fusion of electrophysiological and haemodynamic signals for ventricular rhythm tracking.

L. Thoraval, G. Carrault, J.M. Schleich, R. Summers, M. van de Velde, J. Diaz.
IEEE Eng. Med. Biol., 16, 6: 48-55., 1997.

Publication by ANT staff

Validation of the EEG in ICU patients: classification of signal characteristics and detection of non-stationary events.

M. van de Velde, I.R. Ghosh.
Workshop on Techniques and Interpretation of EEG and Evoked Potentials in Intensive Care and Anaesthesia for IBIS Data Collection, Copenhagen, 11-12th October 1997., Abstract, 1997.

Publication by ANT staff

The use of the +/- average for quality assessment of AEPs in clinical data.

M. van de Velde, N.A.M. de Beer, P.J.M. Cluitmans.
Poster Symposium "Technologie en Wetenschap in de Klinische Neurofysiologie", KNF Technologie Werkgroep, Amsterdam, 7 juni 1996., Poster, 1996.

Publication by ANT staff

Evaluation of automatic quality assessment of auditory evoked potentials in clinical data.

M. van de Velde, N.A.M. de Beer, P.J.M. Cluitmans.
Proc. IEEE Eng. Med. Biol. Soc. Conf. 1996, Amsterdam. Paper number: 493., Abstract, 1996.

Publication by ANT staff

Are standard head models superior to the sphere model in MEG source localization

F. Zanow, R. Verhoef, T.R. Knoesche, M.J. Peters
Biomagnetism: Fundamental research and clinical applications C. Baumgartner et al. (eds.), Elsevier Science, IOS Press, 450 - 454, 1995.

Publication by ANT staff

Clinical evaluation of a method for automatic detection and removal of artifacts in auditory evoked potential monitoring

N.A.M. de Beer, M. van de Velde, P.J.M. Cluitmans.
J. Clin. Monit., 11(6): 381-391, 1995.

Publication by ANT staff

Individually shaped volume conductor models of the head in EEG source localisation

F. Zanow, M.J. Peters
Med Biol Eng Comput, 33(4):582-8. , 1995.

Publication by ANT staff

Localizing sources within the human brain by means of MEG and EEG

M.J. Peters, S.P. van den Broek, T.R. Knoesche, F. Zanow
New Prospects in Psychiatry: The bioclinical interface, J.P. Macher, A.A. Crocq, J.F. Nedelec (eds.) John Libbey Eurotext, Paris, 399-404 , 1995.

Publication by ANT staff

Development and implementation of a data-acquisition system for an international clinical study.

M. van de Velde, L.J.M. Cluitmans, H.M. Kuipers, P.J.M. Cluitmans, J.T. Moller.
Proc. 3rd European Conf. Eng. Med. (ESEM 1995, Florence)., Abstract, 1995.

Publication by ANT staff

The MUSIC approach in EEG source localization

T.R. Knoesche, F. Zanow, M.J. Peters, T.C. Gunter, H. Brauer
Qualitative and topological EEG and MEG analysis, M. Eiselt, U. Zwiener, H. Witte (eds.), Universitatsverlag Jena, 269-273, 1995.

Publication by ANT staff

Measuring auditory evoked potentials during sleep; methods for clinical use.

M. van de Velde, P.J.M. Cluitmans, A.C. Declerk, H.M.J.C. Verbeek, L. Beecher, P. Griep.
Electroenceph. clin. Neurophysiol., Society proc. Dutch Society for EEG and Clinical Neurophysiology., 90: P2, 1994.

Publication by ANT staff

Reconstruction of brain activity from EEG

T.R. Knoesche, M.J. van Burik and M.J. Peters
Supercomputing in brain research: From tomography to neural networks, H.J.Herrmann et al. eds, World Science, pp 199-204, 1994.

Publication by ANT staff

Assessment of methods for measuring middle latency auditory evoked potentials in humans during sleep.

M. van de Velde, P.J.M. Cluitmans, A.C. Declerk, P. Griep, L. Beecher, H.M.J.C. Verbeek, E. Voets.
In: Sleep-Wake Research in The Netherlands. Leiden: Dutch Society for Sleep-Wake Research, ISBN 90-73675-04-9., 4; 195-199., 1993.

Publication by ANT staff

Optimization of stimulation frequency in middle latency auditory evoked potentials in humans.

M. van de Velde, P.J.M. Cluitmans, A.C. Declerk
Technology and Health Care, Proc. 2nd European Conf. Eng. Med. (ESEM 1993, Stuttgart), 1: 340-341, 1993.

Publication by ANT staff

Spracheingabe fuer Expertensysteme. Neuronale Netze und phonematische Entscheidungsmodelle.

N. Pezer
Arbeitspapiere der GMD, 719, 1992.

Publication by ANT staff

Projekt DUBRAVA. Rechnen und Gestalten mit neuronalen Netzen.

N. Pezer
Arbeitspapiere der GMD, 720, 1992.

Publication by ANT staff

Erzeugungsmechanismen und Schallcharakteristika der Frikative und Affrikaten.

N. Pezer
Forum Phoneticum, H Buske Verlag, 33, 1985.

Publication by ANT staff

Erfassung von schnellen und langsamen Kehlkopfbewegungen beim Sprechen.

N. Pezer
Forschungsberichte des Instituts fuer Phonetik und sprachliche Kommunikation der Universitat Muenchen, 19, 1984.

Publication by ANT staff

Gewinnung der Glottisfrequenz aus den Vibrationen des Kehlkopfes.

N. Pezer
Forschungsberichte des Instituts fuer Phonetik und sprachliche Kommunikation der Universitat Muenchen, 17, 1983.

Publication by ANT staff

Production of Whistled Speech

N. Pezer, A. Almeida
Tenth International Congress of Phonetics, 10, 1983.

Publication by ANT staff

Schnelle Hardware fuer Fourier-Analyse

N. Pezer
Berichte des Instituts fuer Phonetik der Universitat zu Koeln, 11, 1982.

Publication by ANT staff

Visuelle Kontrolle akustischer Parameter. Zur Entwicklung apparativer Hilfsmittel fuer den Unterricht mit Hoersprachgeschadigten.

N. Pezer, T. Grunwald
Hoergeschadigten Padagogik, 6, 1981.

Publication by ANT staff